Glands in the mucous-membrane lining of the stomach, called peptic chief cells, are responsible for making pepsinogen. This happens after they are stimulated by the vagus nerve and hormonal secretions of gastrin and secretin.
Pepsinogen mixes with hydrochloric acid and is then converted to the active enzyme pepsin. Pepsin has maximal activity in acidic environments, ideally around a pH of about 1. It then causes pepsin to be neutralized and denatured. This is important because inside the stomach is intended to be an acidic place. Yes, it is an endopeptidase that breaks down proteins into shorter polypeptide chains. Technically, it is an aspartic protease and one of three principal proteases in the human digestive system.
Amino acids must be broken down before readily being absorbed by the small intestine. Once pepsin degrades proteins into smaller peptides, peptides are then absorbed from the intestine into the bloodstream or further broken down by pancreatic enzymes.
Some pepsin is capable of passing from the stomach into the bloodstream, where it continues to breaks down undigested fragments of protein.
These include phenylalanine, tryptophan and tyrosine. This is also believed to help keep the stomach free of most bacteria.
How does pepsin work in the body? Its main function is to break down or denature proteins, but it also has other roles, including facilitating nutrient absorption and killing harmful microbes. The role of digestive enzymes is primarily to act as catalyst in chemical reactions in the body. Digestive enzymes turn larger molecules into more easily absorbed particles that the body can actually use to survive and thrive. There are several main reasons why some people can benefit from taking pepsin enzymes.
Pepsin benefits and uses include:. Although pepsin is an important digestive enzyme with many benefits, there are several digestive problems that are linked to dysfunction of pepsin. These include:. Foods in your diet do not actually contain pepsin, but they can affect your production of stomach acid and digestive enzymes.
The volume you produce increases if you eat high volumes of protein. Pepsin medications and supplements are also sources of pepsin. These are used to enhance digestion of food especially proteins when someone lacks proper pepsin secretion. They help manage conditions like pancreatitis as well.
Pepsin supplements are usually produced from hog or swine pig stomachs. The product called betaine hydrochloride or betaine HCL with pepsin is recommended by some practitioners a supplemental source of hydrochloric acid for people who have low stomach acid production also called hypochlorhydria. This may help hydrochloric acid secreted by the stomach better convert pepsinogen and aid in digestion of protein. Plus, it may offer other benefits like reducing allergies and inhibiting the overgrowth of candida.
Pepsin is a digestive enzyme produced by the body to digest protein-containing foods in the stomach by breaking these proteins into smaller peptides — an enzyme with this function is called a Protease. Pepsin works in conjunction with stomach acid to support protein digestion. As well as providing natural digestive support, Pepsin can also help promote healthy levels of stomach acidity and a normal gastric function. Our Pepsin products include complexes containing Pepsin among other ingredients for a strong, tailored approach to remedying ailments and alleviating their symptoms.
Showing 1 - 4 of 4. Show 12 24 48 All per page. Grid view. The tablets are designed to dissolve in the stomach where the acidity is required. Read more. To ensure optimal digestion, an individual should make sure to have adequate HCl content in the stomach. This product is contraindicated in an individual with a history of hypersensitivity to any of its ingredients. Only logged in customers who have purchased this product may leave a review.
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